The Resident Evil 4 remake has a critical but highly specific bug that could stop players from continuing. In Chapter 12, when players receive a specific key item, Capcom asks players to not attack with a knife until the notification for successfully obtaining that item has appeared in the upper right corner.

The item should then appear in the attache case's key items and treasures. If it hasn't, players should reload their save file before Chapter 12.

Capcom says it will push out a future update to fix the bug.