Developer Insomniac Games announced Marvel's Spider-Man 2 during PlayStation's September 2021 Showcase. The game is scheduled to release for PS5.

During the showcase, we also got a new trailer for Spider-Man 2. In it, we see both Peter Parker and Miles Morales working together as the two Spider-Men of New York while a narrator (who sounds an awful lot like Kraven the Hunter) asks if anyone will give him the challenge he desires. And then Venom appears, answering that they will provide that challenge.

As suspected by fans, Spider-Man 2 takes place after the events of both Marvel's Spider-Man and Marvel's Spider-Man: Miles Morales. How much later remains to be seen, but we'll likely learn more as we get closer to its scheduled launch date of 2023.