The Mural Cave is one of the locations in Resident Evil 4. You'll stumble upon this area after beating the Del Lago boss, whereupon you'll have to find a couple of important items. This will, eventually, lead you to the Church proper. Here's our Resident Evil 4 Mural Cave Puzzle and Church Puzzle guide to help you complete this section of the campaign.
Resident Evil 4 Mural Cave Puzzle and Church Puzzle guide
As mentioned above, the Resident Evil 4 Mural Cave Puzzle is accessed once you're done with the Del Lago encounter. This will take you to a pier where you have to run from a couple of enemy mobs. Soon, you'll reach the Mural Cave. The shrine in the center has the key you need, but you still need to find two items. A nearby drawing on the cave wall will mark the two locations on your map.
Location #1
Before you do anything else, return to the Dockyard, the one with the Merchant and the Shooting Gallery. You'll want to do a manual save in case things go awry. Anyway, once you're ready, head to the nearby location and dock at the pier. The gate is locked, so you'd have to circle around while battling numerous cursed villagers.